Clinical efficacy of shenzhe zhuyun mixture in treating esophageal lesion in patients with systemic sclerosis

• Published in: Zhongguo Zhong xi yi jie he za zhi Vol. 25; no. 11; p. 971
• Main Authors: Guo, Gang, Dong, Shu-yun, Zhao, Yong-wu
• Format: Journal Article
• Language: Chinese
• Published: China 01.11.2005
• Subjects: Adolescent; Adult; Aged; Double-Blind Method; Drugs, Chinese Herbal - therapeutic use; Esophageal Diseases - drug therapy; Esophageal Diseases - etiology; Esophageal Diseases - physiopathology; Esophagus - physiopathology; Female; Humans; Male; Middle Aged; Phytotherapy; Scleroderma, Systemic - complications; Scleroderma, Systemic - drug therapy
• ISSN: 1003-5370

To investigate the clinical efficacy of Shenzhe Zhuyun mixture (SZM) in treating esophageal lesion in patients with systemic sclerosis. Sixty-four patients conforming to the inclusion criteria were randomly divided into 2 groups, the treated group and the control group treated respectively by SZM and cisapride, with the blank preparation imitating the contrast one, the treatment course to both groups was 2 months. The clinical efficacy, the changes in symptom scores of esophageal lesion, the orthostatic and clinostatic time of barium passing through esophagus, the clinostatic esophageal emptying index of barium, and the widest transverse diameter of ectatic esophageal segment, as well as the influence of treatment on patients' quality of life were observed. The total effective rate in the treated group was superior to that in the control group (96.9% vs 56.2%, P < 0.01). Symptom of esophageal lesion was significantly improved after treatment in both groups (P<0.01), and the improvement in the treated group wa