Cardiomyocyte culture as a highly sensitive system for testing pharmacological activity of specific bradycardic agents

Two antiarrhythmic agents were studied: verapamil and bradizole, a new bradycardic drug. It was found that both drugs exhibit a dose-dependent negative chronotropic effect on the culture of contractile cardiomyocytes of newborn rats. Bradizole showed more pronounced bradycardic properties than verap...

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Bibliographic Details
Published inĖksperimentalʹnaâ i kliničeskaâ farmacologiâ Vol. 69; no. 5; p. 24
Main Authors Neverova, M E, Mkrtumova, N A, Fidelina, O V, Adamskaia, E I, Tsorin, I B, Chichkanov, G G, Chudakov, L I
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.09.2006
Subjects
Animals
Anti-Arrhythmia Agents - pharmacology
Benzimidazoles - pharmacology
Calcium Channel Blockers - pharmacology
Cells, Cultured
Myocardial Contraction
Myocytes, Cardiac - drug effects
Rats
Sulfhydryl Compounds - pharmacology
Verapamil - pharmacology
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Summary:Two antiarrhythmic agents were studied: verapamil and bradizole, a new bradycardic drug. It was found that both drugs exhibit a dose-dependent negative chronotropic effect on the culture of contractile cardiomyocytes of newborn rats. Bradizole showed more pronounced bradycardic properties than verapamil.
ISSN:0869-2092