Influence of Qingxiang San on substance P, somatostatin in rats model with the spleen and stomach wet heat syndrome

• Published in: Zhong yao cai Vol. 31; no. 10; p. 1526
• Main Authors: Tan, Yong-Zhen, Wen, Xiao-Min, Chen, Pei-Chan, Li, Yu-Jing, Chen, Pei-Hong, Huang, Gui-Qiong
• Format: Journal Article
• Language: Chinese
• Published: China 01.10.2008
• Subjects: Animals; Disease Models, Animal; Drug Combinations; Drugs, Chinese Herbal - pharmacology; Female; Gastrointestinal Hormones - metabolism; Male; Plants, Medicinal - chemistry; Pyloric Antrum - drug effects; Pyloric Antrum - metabolism; Radioimmunoassay; Random Allocation; Rats; Rats, Sprague-Dawley; Somatostatin - metabolism; Splenic Diseases - drug therapy; Splenic Diseases - metabolism; Stomach Diseases - drug therapy; Stomach Diseases - metabolism; Substance P - metabolism; Yin Deficiency - drug therapy; Yin Deficiency - metabolism
• ISSN: 1001-4454

To observe the influence of Qingxiang San (QS) on substance P (SP), somatostatin (SS) in rats model of spleen and stomach wet heat syndrome. 24 rats were divided into 3 groups (each group 8 rats) randomly: the normal control group (NCG), wet heat group (WHG), QS group (QSG). We set up the spleen and stomach wet heat syndrome of rats model by the composite factors such as greasy and sweet food, wet and hot environment, pathogen and so on. Then the contents of SP, SS were detected by radioimmuno assay. The content of SP, SS in WHG were obviously lower than NCG (P<0.01); QSG compared with WHG, the content of SP, SS increased (P<0.01); The content of SP obviously increased when QSG compared with NCG (P<0.01); About the content of SS, there was no significant difference between QSG and NCG (P>0.05), illustrating that QS can increase the content of SP, SS which had decreased. QS can regulate the content of SP and SS and increase them which had decreased.