Ischemic postconditioning induces neuroprotection via up-regulation of endogenous antioxidant enzyme activities: experiment with rabbits
To test the hypothesis that spinal cord protection induced by ischemic postconditioning is mediated by an increase of endogenous antioxidant enzyme activities during reperfusion phase in spinal cord. Seventy-eight male New Zealand rabbits were randomly divided into 3 groups: Sham group (n = 18) unde...
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Published in | Zhong hua yi xue za zhi Vol. 88; no. 33; p. 2355 |
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Format | Journal Article |
Language | Chinese |
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China
26.08.2008
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Abstract | To test the hypothesis that spinal cord protection induced by ischemic postconditioning is mediated by an increase of endogenous antioxidant enzyme activities during reperfusion phase in spinal cord.
Seventy-eight male New Zealand rabbits were randomly divided into 3 groups: Sham group (n = 18) undergoing sham operation without aortic occlusion; ischemia/reperfusion (I/R) group (n = 30) undergoing occlusion of the infrarenal abdominal aorta for 20 min, followed by reperfusion; and postconditioning (PostC) group (n = 30) undergoing occlusion of the infrarenal abdominal aorta for 20 min followed by 3 cycles of 30 s reperfusion/30 s ischemia just at the onset of reperfusion. 30 min, and 1, 3, 6, 24, and 48 h after reperfusion 5 rabbits from each group (and 3 from the Sham group) were killed with their spinal cords taken out, and spectrophotometric method was used to determine the antioxidant enzyme activity and malondialdehyde (MDA) content 6, 24, and 48 h after reperfusion motor function scoring of the hind lim |
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AbstractList | To test the hypothesis that spinal cord protection induced by ischemic postconditioning is mediated by an increase of endogenous antioxidant enzyme activities during reperfusion phase in spinal cord.
Seventy-eight male New Zealand rabbits were randomly divided into 3 groups: Sham group (n = 18) undergoing sham operation without aortic occlusion; ischemia/reperfusion (I/R) group (n = 30) undergoing occlusion of the infrarenal abdominal aorta for 20 min, followed by reperfusion; and postconditioning (PostC) group (n = 30) undergoing occlusion of the infrarenal abdominal aorta for 20 min followed by 3 cycles of 30 s reperfusion/30 s ischemia just at the onset of reperfusion. 30 min, and 1, 3, 6, 24, and 48 h after reperfusion 5 rabbits from each group (and 3 from the Sham group) were killed with their spinal cords taken out, and spectrophotometric method was used to determine the antioxidant enzyme activity and malondialdehyde (MDA) content 6, 24, and 48 h after reperfusion motor function scoring of the hind lim |
Author | Meng, Jing-ru Xiong, Li-ze Wang, Hui Cheng, Qiong Lu, Zhi-hong Dong, Hai-long Song, Wen-ying |
Author_xml | – sequence: 1 givenname: Wen-ying surname: Song fullname: Song, Wen-ying organization: Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China – sequence: 2 givenname: Hai-long surname: Dong fullname: Dong, Hai-long – sequence: 3 givenname: Qiong surname: Cheng fullname: Cheng, Qiong – sequence: 4 givenname: Zhi-hong surname: Lu fullname: Lu, Zhi-hong – sequence: 5 givenname: Hui surname: Wang fullname: Wang, Hui – sequence: 6 givenname: Jing-ru surname: Meng fullname: Meng, Jing-ru – sequence: 7 givenname: Li-ze surname: Xiong fullname: Xiong, Li-ze |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19087700$$D View this record in MEDLINE/PubMed |
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SubjectTerms | Animals Antioxidants - metabolism Catalase - metabolism Disease Models, Animal Ischemic Preconditioning - methods Male Rabbits Reperfusion Injury - metabolism Reperfusion Injury - prevention & control Spinal Cord Ischemia - metabolism Spinal Cord Ischemia - prevention & control Superoxide Dismutase - metabolism Up-Regulation |
Title | Ischemic postconditioning induces neuroprotection via up-regulation of endogenous antioxidant enzyme activities: experiment with rabbits |
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