Calpain I inhibition prevents pacing-induced structural remodeling for atrial fibrillation in canine

• Published in: Zhōnghuá xīnxuèguănbìng zázhì Vol. 35; no. 2; p. 132
• Main Authors: Li, Wei-min, Xue, Hong-jie, Li, Yue, Zhang, Li, Gong, Yong-tai, Sheng, Li, Chu, Shan
• Format: Journal Article
• Language: Chinese
• Published: China 01.02.2007
• Subjects: Animals; Atrial Fibrillation - metabolism; Atrial Fibrillation - physiopathology; Atrial Function, Left; Calpain - antagonists & inhibitors; Calpain - metabolism; Cardiac Pacing, Artificial; Disease Models, Animal; Dogs; Heart Atria - ultrastructure; Myocardium - metabolism; Troponin T - metabolism

To study the relation of the structural remodeling processes and activation of calpain I. Fifteen dogs were randomly divided into three groups. The dogs in pacing group (n=5) and inhibitor group (n=5) were subjected to 3 weeks of rapid atrial pacing at 600 beats/min, control dogs (n=5) were in sham-...