Small cell carcinoma of the prostate: a case report

• Published in: Hinyokika kiyo. Acta urologica Japonica Vol. 52; no. 9; pp. 719 - 721
• Main Authors: Sasaki, Mitsuharu, Kobayashi, Takashi, Ono, Kunio, Sugano, Osamu, Sasao, Syunichi, Hoshi, Senji
• Format: Journal Article
• Language: Japanese
• Published: Japan 01.09.2006
• Subjects: Aged; Biomarkers, Tumor - blood; Biopsy; Carcinoma, Small Cell - diagnostic imaging; Carcinoma, Small Cell - pathology; Digital Rectal Examination; Humans; Male; Prostate - pathology; Prostate-Specific Antigen - blood; Prostatic Neoplasms - diagnostic imaging; Prostatic Neoplasms - pathology; Radiography, Abdominal; Tomography, X-Ray Computed
• ISSN: 0018-1994

A 79-year-old man was admitted to our department with a chief complaint of urinary incontinence. The prostate was enlarged (145 cc), although the serum level of prostate specific antigen (PSA) was within the normal range (1.09 ng/ml). Digital rectal examination showed an enlarged, irregular prostate with stony hardness. We performed a prostate biopsy and histological examinations indicated poorly differentiated adenocarcinoma with a Gleason score of 5+5=10. A computed tomographic (CT) scan revealed a prostatic tumor invading the bladder, seminal vesicle and rectum. He was diagnosed with a stage T4N1M0 adenocarcinoma of the prostate. He was started-on hormonal therapy, but died one month from the start of treatment. Histological and immunohistological examinations were repeated; suggesting small cell neuroendocrine carcinoma of the prostate.