Study on the application of benchmark dose and biological monitoring indexes of fluorides in drinking water

• Published in: Zhōnghuá yùfáng-yīxué zázhì Vol. 38; no. 4; p. 261
• Main Authors: Xiang, Quan-Yong, Liang, You-Xin, Chen, Bing-Heng, Wang, Cai-Sheng, Zhen, Shi-Qi, Chen, Lian-Sheng, Zhou, Ming-Sheng, Li, Jie-Fei
• Format: Journal Article
• Language: Chinese
• Published: China 01.07.2004
• Subjects: Adolescent; Child; China - epidemiology; Environmental Monitoring; Epidemiological Monitoring; Female; Fluorides - analysis; Fluorides - blood; Fluorides - urine; Fluorosis, Dental - epidemiology; Humans; Male; Prevalence; Water Supply - analysis; Water Supply - standards; China
• ISSN: 0253-9624

By using Benchmark Dose (BMD) approach to explore the relations among drinking water fluoride, urine fluoride, serum fluoride and dental fluorosis; and to evaluate the significance of urine fluoride and serum fluoride in control and prevention of endemic fluorosis. 512 children (290 in Xinhuai Village, 222 in Wamiao Village) aged 8-13 years were recruited in the study. Epidemiological methods were used to investigate the prevalence of dental fluorosis, and the levels of urine fluoride, serum fluoride, and drinking water fluoride in superficial well. The children were divided into six subgroups by the concentration of fluoride in drinking water: < 0.5 mg/L, 0.5-mg/L, 1.0-mg/L, 2.0-mg/L, 3.0-mg/L and > or = 4.0 mg/L. There was significant dose-response relationship between the drinking water fluoride and the prevalence of dental fluorosis or the prevalence of defect dental fluorosis. The BMDLs (Benchmark Dose Lower Bound) were 1.01 and 1.30 mg/L, respectively. Urine fluoride and serum fluoride also had signific