Study on the antipyretic, analgesic effects of qingkailing freeze-dried powder for injection and its antipyretic mechanism

• Published in: Zhong yao cai Vol. 28; no. 9; p. 796
• Main Authors: Li, Dong, Yang, Fangju, Huang, Jihua, Ling, Jing, Jing, Yan
• Format: Journal Article
• Language: Chinese
• Published: China 01.09.2005
• Subjects: 2,4-Dinitrophenol; Analgesics, Non-Narcotic - pharmacology; Animals; Anti-Inflammatory Agents - pharmacology; Cyclic AMP - biosynthesis; Drugs, Chinese Herbal - pharmacology; Female; Fever - chemically induced; Fever - pathology; Hypothalamus - drug effects; Hypothalamus - metabolism; Interleukin-1 - biosynthesis; Male; Mice; Pain - chemically induced; Pain - drug therapy; Pain - pathology; Plants, Medicinal - chemistry; Powders; Rabbits; Rats; Rats, Sprague-Dawley
• ISSN: 1001-4454

To investigate the antipyretic, analgesic effects of Qingkailing Freeze-Dried Powder for Injection (QI) and its mechanism of the antipyretic effect. The rabbit model of 2, 4-dinitrophenol-induced fever and the rat model of endotoxin-induced fever were established and the body temperatures were observed. Radioimmunoassay was adopted to detect the levels of IL-1beta and cAMP in the hypothalamus of rats. The analgesic effects were tested by hot-plate and writhing reaction method. QI showed marked antipyretic effects on the 2,4-dinitrophenol-induced fever and the endotoxin-induced fever. At the same time, QI remarkably decreased the contents of IL-beta and cAMP in the hypothalamus. QI also remarkably reduced the frequency of acetic acid-induced writhing and delaied the time of licking rear feet. QI has antipyretic, analgesic effects. Its mechanism of the antipyretic effects on rats may be inhibiting the production of IL-1beta and accordingly decreasing cAMP in the hypothalamus.