Beneficial effect of a moisturizing cream as adjunctive treatment to oral isotretinoin or topical tretinoin in the management of acne

Despite their beneficial effects on the treatment of acne vulgaris, topical and oral retinoids may cause severe local irritation (retinoid dermatitis) due to their mechanism of action, thereby jeopardizing patient adherence, and thus compromising treatment efficacy. Alleviating dryness and improving...

Full description

Saved in:
Bibliographic Details
Published inJournal of drugs in dermatology Vol. 5; no. 10; p. 985
Main Authors Laquieze, Sabine, Czernielewski, Janusz, Rueda, Marie-José
Format Journal Article
LanguageEnglish
Published United States 01.11.2006
Subjects
Acne Vulgaris - drug therapy
Administration, Cutaneous
Administration, Oral
Adolescent
Adult
Dermatitis, Exfoliative - prevention & control
Drug Administration Schedule
Drug Synergism
Drug Therapy, Combination
Electric Capacitance
Emollients - administration & dosage
Emollients - therapeutic use
Female
Humans
Isotretinoin - administration & dosage
Isotretinoin - therapeutic use
Keratolytic Agents - administration & dosage
Keratolytic Agents - therapeutic use
Male
Patient Satisfaction - statistics & numerical data
Skin - drug effects
Skin - physiopathology
Surveys and Questionnaires
Time Factors
Treatment Outcome
Tretinoin - administration & dosage
Tretinoin - therapeutic use
Water Loss, Insensible - drug effects
Online AccessGet more information

Cover

More Information
Summary:Despite their beneficial effects on the treatment of acne vulgaris, topical and oral retinoids may cause severe local irritation (retinoid dermatitis) due to their mechanism of action, thereby jeopardizing patient adherence, and thus compromising treatment efficacy. Alleviating dryness and improving skin comfort by using a moisturizer concomitantly to retinoids could enhance efficacy. In the present study, 30 subjects receiving either oral isotretinoin for at least 2 months or topical tretinoin for at least one month applied a moisturizing cream (Cetaphil Moisturizing Cream) twice daily for 15 days on one half of the face while the other side remained untreated. Clinical assessments, confirmed by biophysical measurements, showed that the moisturizer provided a significant improvement in skin dryness, roughness, and desquamation. Skin properties and skin discomfort were also greatly improved and subjects were very satisfied with the product. Retinoid-induced skin irritation can be relieved by the regular use of a gentle moisturizing cream as an adjunctive treatment.
ISSN:1545-9616