The injection pain of propofol with different emulsion

• Published in: Masui. The Japanese journal of anesthesiology Vol. 55; no. 3; p. 338
• Main Authors: Kinoshita, Maho, Morioka, Nobutada, Takada, Mikiko, Ozaki, Makoto
• Format: Journal Article
• Language: Japanese
• Published: Japan 01.03.2006
• Subjects: Anesthesia, Intravenous; Anesthetics, Intravenous - administration & dosage; Anesthetics, Intravenous - adverse effects; Cross-Over Studies; Double-Blind Method; Emulsions; Female; Humans; Injections, Intravenous; Male; Middle Aged; Pain - etiology; Pain Measurement; Propofol - administration & dosage; Propofol - adverse effects; Prospective Studies; Triglycerides - chemistry
• ISSN: 0021-4892

Incidence and intensity of pain on intravenous injection of propofol were assessed with emulsion of long-chain/medium-chain triglycerides (LCT/MCT, 50: 50) and only long-chain triglycerides (LCT, 100) in patients undergoing different elective surgical interventions in this prospective, randomized, cross over and double-blinded study. 1) Forty six patients were assigned to two groups. One group received 0.2 mg x kg(-1) LCT/ MCT propofol prior to LCT propofol administration. The other group received 0.2 mg x kg(-1) LCT propofol prior to LCT/MCT propofol administration. Pain elicited upon questioning was assessed with each injection in the two groups. Patients were asked to grade the pain as VAS of 0 to 100 mm. 2) Fifty one patients were randomly assigned to two groups. One group received 0.4 mg x kg(-1) LCT propofol. The other group received 0.4 mg x kg(-1) LCT/MCT propofol. Patients were asked to grade the pain as VAS of 0 to 100 mm. Pain of LCT propofol injection was stronger than LCT/MCT propofol. As incidence of 0.4 mg x kg(-1) propofol injection, VAS on LCT/MCT propofol and LCT propofol gave score as 0 and 23.5 (P=0.0019). Propofol with emulsion of long- and medium-chain triglycerides appears to reduce the injection pain than with emulsion of only long-chain triglycerides.