Analysis of cholesterol ester transfer protein gene Taq IB and -629 C/A polymorphisms in patients with endogenous hypertriglyceridemia in Chinese population

To investigate the variations of cholesterol ester transfer protein (CETP) gene and its relation to endogenous hypertriglyceridemia (HTG) in Chinese population. One hundred and thirty-five endogenous hypertriglyceridemics and 214 healthy subjects from a population of Chinese Han nationality in Cheng...

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Published inZhonghua yi xue yi chuan xue za zhi Vol. 23; no. 6; p. 640
Main Authors Wu, Yin, Bai, Huai, Liu, Rui, Liu, Yu, Liu, Bing-wen
Format Journal Article
LanguageChinese
Published China 01.12.2006
Subjects
Adult
Aged
Aged, 80 and over
Apolipoproteins - blood
Asian Continental Ancestry Group - genetics
China
Cholesterol Ester Transfer Proteins - genetics
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Deoxyribonucleases, Type II Site-Specific - metabolism
DNA - genetics
DNA - metabolism
Female
Gene Frequency
Genotype
Humans
Hypertriglyceridemia - blood
Hypertriglyceridemia - ethnology
Hypertriglyceridemia - genetics
Linkage Disequilibrium
Male
Middle Aged
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
Triglycerides - blood
China
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Summary:To investigate the variations of cholesterol ester transfer protein (CETP) gene and its relation to endogenous hypertriglyceridemia (HTG) in Chinese population. One hundred and thirty-five endogenous hypertriglyceridemics and 214 healthy subjects from a population of Chinese Han nationality in Chengdu area were studied using restriction fragment length polymorphism (RFLPs) amplified by polymerase chain reaction (PCR). The polymorphic sites studied included Taq IB and -629 C/A polymorphism in CETP gene. The frequencies of B(2) allele at Taq IB site in normal group and HTG group were 0.418 and 0.382, respectively. The frequencies of A allele at -629 C/A site in the two groups were 0.479 and 0.489, respectively. No significant difference between normal control and HTG groups were found in both allele frequency of the two polymorphism. Linkage disequilibrium was observed between Taq IB and -629 C/A polymorphic sites (D'=0.881). In the normal control group, subjects with genotype B(2)B(2) of Taq IB site had a high
ISSN:1003-9406