Analysis of SNPs and enzymatic disorder in the patients of influenza-associated encephalopathy: disorder of fatty acid metabolism in mitochondria induced by high fever

To assess the etiology of influenza-associated encephalopathy(IAE), a surveillance effort was conducted during 2000-2005 in Japan. Over half of fatal and handicapped IAE patients exhibited a disorder of mitochondrial beta-oxidation and ATP generation evoked by the thermolabile phenotype of carnitine...

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Bibliographic Details
Published inNihon rinshō Vol. 64; no. 10; p. 1879
Main Authors Kido, Hiroshi, Yao, Dengbing, Le Trong, Quang, Tsukane, Mariko, Chida, Junji
Format Journal Article
LanguageJapanese
Published Japan 01.10.2006
Subjects
Animals
Brain Diseases - etiology
Carnitine O-Palmitoyltransferase - genetics
Carnitine O-Palmitoyltransferase - metabolism
Fatty Acids - metabolism
Humans
Influenza, Human - complications
Mice
Mitochondria - metabolism
Polymorphism, Single Nucleotide
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Summary:To assess the etiology of influenza-associated encephalopathy(IAE), a surveillance effort was conducted during 2000-2005 in Japan. Over half of fatal and handicapped IAE patients exhibited a disorder of mitochondrial beta-oxidation and ATP generation evoked by the thermolabile phenotype of carnitine palmitoyltransferase II variations with transiently elevated serum acylcarnitine during high-grade fever. Model mice having impaired mitochondrial beta-oxidation exhibited significant accumulation of mini-plasmin and up-regulation of trypsin in the cerebral capillaries after infection with influenza A virus, resulting in the destruction of blood-brain barrier and increased brain vascular permeability. Trypsin up-regulation was also evident in the neuronal cells in the hippocampus, suggesting a severe neurologic complication of IAE.
ISSN:0047-1852