The capacity of mesenchymal stem cells for neural differentiation in vitro

It has been shown that mesenchymal stem cells (MSCs) of bone marrow from newborn rabbits can be induced for neuronal differentiation. The epidermal growth factor (EGF) introduced in the culture at the rate of 2 ng/ml is able to promote differentiation of neurons from bone marrow mesenchymal stem cel...

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Bibliographic Details
Published inT͡S︡itologii͡a Vol. 47; no. 7; p. 644
Main Authors Zemchikhina, V N, Golubeva, O N
Format Journal Article
LanguageEnglish
Published Russia (Federation) 2005
Subjects
Animals
Animals, Newborn
Bone Marrow Cells - cytology
Cell Differentiation
Cells, Cultured
Culture Media
Epidermal Growth Factor
Mesenchymal Stromal Cells - cytology
Molecular Weight
Neurofilament Proteins - analysis
Neurofilament Proteins - chemistry
Neurons - cytology
Neurons - metabolism
Rabbits
Time Factors
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Summary:It has been shown that mesenchymal stem cells (MSCs) of bone marrow from newborn rabbits can be induced for neuronal differentiation. The epidermal growth factor (EGF) introduced in the culture at the rate of 2 ng/ml is able to promote differentiation of neurons from bone marrow mesenchymal stem cells in 27 days of cultivation. Differentiated cells were marked by monoclonal antibodies to 70 kDa neurofilaments. The data obtained show a possibility of using bone marrow stem cells in therapy of neurodegenerative diseases.
ISSN:0041-3771