Strategies for exploiting microbial lipase resource and improving lipase biocatalyst--a review

Lipase plays a very important role in food, pharmaceutical, fine chemical and bio-energy industries. Obtaining microbial lipase resource and improving their biocatalyst are important. Based on protein engineering and molecular techniques, directed evolution, hybrid enzyme, surface display give effec...

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Bibliographic Details
Published inWei sheng wu hsüeh pao Vol. 48; no. 9; p. 1276
Main Authors Jinyong, Yan, Yunjun, Yan
Format Journal Article
LanguageChinese
Published China 01.09.2008
Subjects
Bacterial Proteins - chemistry
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Catalysis
Fungal Proteins - chemistry
Fungal Proteins - genetics
Fungal Proteins - metabolism
Industrial Microbiology
Lipase - chemistry
Lipase - genetics
Lipase - metabolism
Protein Engineering
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Summary:Lipase plays a very important role in food, pharmaceutical, fine chemical and bio-energy industries. Obtaining microbial lipase resource and improving their biocatalyst are important. Based on protein engineering and molecular techniques, directed evolution, hybrid enzyme, surface display give effective approaches to obtain novel lipase biocatalysts. By physical and chemical modification approaches such as bio-imprinting, pH memory, oriented immobilization, cross-linked enzyme crystal and lipid-coated enzyme, more broad and suitable characteristics of modified lipases are achieved. In conclusion, strategies for exploitation of microbial lipase resource and improvement of lipase biocatalyst will accelerate industrial application of lipase.
ISSN:0001-6209