Treatment of men with flat (FC) or acuminata (CA) condylomata with interferon alpha-2a

This study was undertaken to assess the effect of CO2 laser vaporization, 5-fluorouracil 5% (5-FU) topical application and Interferon alpha-2a (IFA alpha-2a) in the treatment of C.A. or F.C. of the male genital tract. From March 1986 to September 1991, 1372 men, sexual partners of women with F.C. or...

Full description

Saved in:
Bibliographic Details
Published inEuropean journal of gynaecological oncology Vol. 17; no. 6; p. 529
Main Authors Relakis, K, Cardamakis, E, Korantzis, A, Metalinos, K, Mantouvalos, H, Papathanasiou, Z, Michopoulos, J, Stathopoulos, E, Kotoulas, I G, Tzingounis, V
Format Journal Article
LanguageEnglish
Published Italy 1996
Subjects
Administration, Topical
Adult
Analysis of Variance
Antimetabolites, Antineoplastic - administration & dosage
Antimetabolites, Antineoplastic - therapeutic use
Antiviral Agents - administration & dosage
Antiviral Agents - therapeutic use
Carbon Dioxide - therapeutic use
Combined Modality Therapy
Condylomata Acuminata - pathology
Condylomata Acuminata - therapy
Dose-Response Relationship, Drug
Fluorouracil - administration & dosage
Fluorouracil - therapeutic use
Genital Diseases, Male - etiology
Genital Diseases, Male - pathology
Genital Diseases, Male - therapy
Humans
Interferon-alpha - administration & dosage
Interferon-alpha - therapeutic use
Laser Therapy
Male
Prospective Studies
Recombinant Proteins
Treatment Outcome
Online AccessGet more information

Cover

More Information
Summary:This study was undertaken to assess the effect of CO2 laser vaporization, 5-fluorouracil 5% (5-FU) topical application and Interferon alpha-2a (IFA alpha-2a) in the treatment of C.A. or F.C. of the male genital tract. From March 1986 to September 1991, 1372 men, sexual partners of women with F.C. or C.A. or cervical intraepithelial neoplasia, were submitted to peoscopy. One thousand and nineteen (74.27%) men presented with various penile lesions caused by HPV (histologically confirmed); of these 505 were treated for C.A. or F.C. or a combination of F.C. and C.A. The best treatment modalities, irrespective of the kind of lesion, were found to be the combination of 5-FU plus IFN alpha-2a (high dose) (98.27%), the combination of CO2 laser vaporization plus 5-FU plus IFN alpha-2a (high dose) (93.93%) and the combination of CO2 laser vaporization plus 5-FU (87.23%). In conclusion we believe that IFN alpha-2a can be used with excellent results as first line treatment in combination with CO2 laser vaporization or/plus 5-FU in patients with C.A. or F.C. or combined condylomata.
ISSN:0392-2936