False-positive ELISA reactions for the hepatitis C virus and the human immunodeficiency virus after anti-influenzal vaccination

Possible appearance of ELISA false-positive results for hepatitis C virus (HCV) and human immunodeficiency virus (HIV) after vaccination against influenza was studied on 402 volunteers before, and 30 and 90 days after that. Our results prove that influenza vaccine can sometimes induce false-positive...

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Bibliographic Details
Published inBacteriologia, virusologia, parazitologia, epidemiologia (Bucharest, Romania : 1990) Vol. 40; no. 3-4; p. 249
Main Authors Ioniţă, E, Lupulescu, E, Alexandrescu, V, Chiriţă, C, Bălteanu, M, Neguţ, A E
Format Journal Article
LanguageEnglish
Romanian
Published Romania 01.07.1995
Subjects
Adolescent
Adult
Antibodies, Viral - blood
Child
Child, Preschool
Cross Reactions
Enzyme-Linked Immunosorbent Assay - methods
Enzyme-Linked Immunosorbent Assay - statistics & numerical data
False Positive Reactions
Hepacivirus - immunology
HIV Antibodies - blood
Humans
Influenza A virus - immunology
Influenza B virus - immunology
Influenza Vaccines - adverse effects
Influenza Vaccines - immunology
Middle Aged
Time Factors
Vaccines, Inactivated - adverse effects
Vaccines, Inactivated - immunology
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Summary:Possible appearance of ELISA false-positive results for hepatitis C virus (HCV) and human immunodeficiency virus (HIV) after vaccination against influenza was studied on 402 volunteers before, and 30 and 90 days after that. Our results prove that influenza vaccine can sometimes induce false-positive ELISA for HCV, but not for HIV. Their frequency is relatively small--0.96% in 10-20-years-old group and 3.1% in over 60 years age, while in 3-6 years age there were not registered this kind of reactions. The surveillance of individual ELISA-positive cases over time proves that cross-reacting antibodies HCV raised after vaccination against influenza are present only in second sera, that means 30 days after vaccination, but these antibodies disappeared 90 days later.
ISSN:1220-3696