Fast in vivo 23Na imaging and T2∗ mapping using accelerated 2D‐FID UTE magnetic resonance spectroscopic imaging at 3 T: Proof of concept and reliability study

• Published in: Magnetic resonance in medicine Vol. 85; no. 4; pp. 1783 - 1794
• Main Authors: Alhulail, Ahmad A., Xia, Pingyu, Shen, Xin, Nichols, Miranda, Volety, Srijyotsna, Farley, Nicholas, Thomas, Micheal Albert, Nagel, Armin M., Dydak, Ulrike, Emir, Uzay E.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc 01.04.2021
• Subjects: Coefficient of variation; Data acquisition; fast; In vivo methods and tests; Magnetic resonance imaging; Magnetic resonance spectroscopy; MRSI; Muscles; OVS localization; quantification; Reliability analysis; Reproducibility; Skeletal muscle; skeletal muscles; sodium; Spatial distribution; T2 mapping; Two dimensional models
• ISSN: 0740-3194; 1522-2594
• DOI: 10.1002/mrm.28576

Purpose To implement an accelerated MR‐acquisition method allowing to map T2∗ relaxation and absolute concentration of sodium within skeletal muscles at 3T. Methods A fast‐UTE‐2D density‐weighted concentric‐ring‐trajectory 23Na‐MRSI technique was used to acquire 64 time points of FID with a spectral bandwidth of 312.5 Hz with an in‐plane resolution of 2.5 × 2.5 mm2 in ~15 min. The fast‐relaxing 23Na signal was localized with a single‐shot, inversion‐recovery‐based, non‐echo (SIRENE) outer volume suppression (OVS) method. The sequence was verified using simulation and phantom studies before implementing it in human calf muscles. To evaluate the 2D‐SIRENE‐MRSI (UTE = 0.55 ms) imaging performance, it was compared to a 3D‐MRI (UTE = 0.3 ms) sequence. Both data sets were acquired within 2 same‐day sessions to assess repeatability. The T2∗ values were fitted voxel‐by‐voxel using a biexponential model for the 2D‐MRSI data. Finally, intra‐subject coefficients of variation (CV) were estimated. Results The MRSI‐FID data allowed us to map the fast and slow components of T2∗ in the calf muscles. The spatial distributions of 23Na concentration for both MRSI and 3D‐MRI acquisitions were significantly correlated (P < .001). The test–retest analysis rendered high repeatability for MRSI with a CV of 5%. The mean T2Fast∗ in muscles was 0.7 ± 0.1 ms (contribution fraction = 37%), whereas T2Slow∗ was 13.2 ± 0.2 ms (63%). The mean absolute muscle 23Na concentration calculated from the T2∗‐corrected data was 28.6 ± 3.3 mM. Conclusion The proposed MRSI technique is a reliable technique to map sodium’s absolute concentration and T2∗ within a clinically acceptable scan time at 3T.