Monte Carlo study on the gold and gadolinium nanoparticles radio-sensitizer effect in the prostate 125I seeds radiotherapy

• Published in: Polish journal of medical physics and engineering Vol. 25; no. 3; pp. 165 - 169
• Main Authors: Ghasemi-Jangjoo, Amir, Ghiasi, Hosein
• Format: Journal Article
• Language: English
• Published: Warsaw Sciendo 01.09.2019; De Gruyter Poland
• Subjects: brachytherapy; brachytherapy seed; Computed tomography; Computer simulation; Dose Enhancement Factor; Dosimeters; Energy; Gadolinium; Gold; gold nano-particles radiotherapy; Humanoid; Measuring instruments; Monte Carlo; Nanoparticles; Organs; Photoelectricity; Prostate; Prostate cancer; Radiation therapy; Seeds; TLD
• ISSN: 1425-4689; 1898-0309
• DOI: 10.2478/pjmpe-2019-0022

Monte Carlo and TL dosimetry applied to the characterization of I brachytherapy with a different design with other I seeds. In a water phantom, lattice configuration simulated with I seed in the center and 10 nm gold and gadolinium nan-particle filed voxels. This simulation conducted to the characterization of the nano-particles DEF in low energy and prostate tissue. To study of the prostate brachytherapy, a humanoid computational phantom developed by CT slices applied. KTMAN-2 computational phantom contains 29 organs and 19 skeletal regions and was produced from cross-sectional x-ray computed tomography (CT slices) images. The simulated seed was I seed having an average energy of 28.4 keV for photons, a half-life of 59.4 days. DEF factor in the seed radiation energy (28.4 keV) DEF factor was found to be two times higher for the gold nano-particles. It was revealed than gold-nano-particles posing Z about 1.24 times higher than gadolinium led to around 200% DEF increasing in the same conditions and the nano-particles size. It was concluded that in low energy sources brachytherapy, photoelectric is dominant in the presence of relative high element nanoparticles. This leads to a high dose increasing in some micro-meters and causes a dramatic dose gradient in the vicinity of a nano-particle. This dose gradient effectively kills the tumor cells in continuous low energy irradiation in the presence of a high Z material nano-scaled particle. Application of gold nano-particles in low energy brachytherapy is recommended.