Clinical application of GnRHa before uterine myomectomy: report of 20 cases

• Published in: Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA Vol. 24; no. 3; p. 317
• Main Authors: Yu, Yan-hong, Gong, Shi-peng, Wan, Shu-mei
• Format: Journal Article
• Language: Chinese
• Published: China 01.03.2004
• Subjects: Adult; Combined Modality Therapy; Female; Gonadotropin-Releasing Hormone - analogs & derivatives; Gonadotropin-Releasing Hormone - therapeutic use; Humans; Leiomyoma - drug therapy; Leiomyoma - pathology; Leiomyoma - surgery; Pregnancy; Retrospective Studies; Uterine Neoplasms - drug therapy; Uterine Neoplasms - pathology; Uterine Neoplasms - surgery
• ISSN: 1000-2588

To study the clinical application of GnRHa prior to uterine myomectomy and its effect on the clinical outcome of pregnancy. A retrospective review of the medical records in 20 cases of uterine myomectomy over a period of 6 years was performed. The changes of uterus and myoma volumes in response to preoperative GnRHa was observed, and the rate of relapse in the follow-up, time of impregnation, spontaneous abortion after the impregnation, time of delivery after the operation and the aura threatening uterine rupture, and uterine rupture during the delivery were assessed. Application of GnRHa produced significant improvement in the clinical symptoms and resulted in obviously reduced volumes of the uterus and myoma. The myoma volume reduction was close to 50% in these cases, and relapse occurred in only 1 case. No spontaneous abortion was found after GnRHa application. The average time of pregnancy was 34+/-3.5 weeks, and aura for uterine rupture was found in 1 case at 33 weeks of pregnancy after GnRHa application