Synthesis of 2,3-dihydroinosine derivatives by reduction using BH3-THF

A novel reductive method for the chemical modification of nucleosides is described. Reaction of inosine derivatives with boran-THF resulted in the regioselective reduction of purine ring to afford the corresponding 2,3-dihydroinosine derivatives in moderate yields.

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Bibliographic Details
Published inNucleic acids symposium series (1979) no. 44; pp. 113 - 114
Main Authors Hirota, K, Hattori, R, Sajiki, H, Monguchi, Y, Muraoka, O, Tanabe, G
Format Journal Article
LanguageEnglish
Published England 2000
Subjects
Boranes
Inosine - analogs & derivatives
Inosine - chemical synthesis
Inosine - chemistry
Models, Molecular
Molecular Structure
Oxidation-Reduction
Stereoisomerism
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Summary:A novel reductive method for the chemical modification of nucleosides is described. Reaction of inosine derivatives with boran-THF resulted in the regioselective reduction of purine ring to afford the corresponding 2,3-dihydroinosine derivatives in moderate yields.
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ISSN:0261-3166