A polymorphism in the human timeless gene is not associated with diurnal preferences in normal adults

• Published in: Sleep research online Vol. 3; no. 2; p. 73
• Main Authors: Pedrazzoli, M, Ling, L, Finn, L, Kubin, L, Young, T, Katzenberg, D, Mignot, E
• Format: Journal Article
• Language: English
• Published: United States 2000
• Subjects: Adult; Alleles; Cell Cycle Proteins; Circadian Rhythm - genetics; Circadian Rhythm - physiology; DNA - genetics; Female; Gene Frequency; Genotype; Humans; Intracellular Signaling Peptides and Proteins; Male; Middle Aged; Polymorphism, Single Nucleotide; Transcription Factors - genetics

The effect of a single nucleotide polymorphism, a glutamine to arginine amino acid substitution in the human Timeless gene (Q831R, A2634G), on diurnal preferences was studied in a random sample of normal volunteers enrolled in a population-based epidemiology study of the natural history of sleep dis...