A polymorphism in the human timeless gene is not associated with diurnal preferences in normal adults

The effect of a single nucleotide polymorphism, a glutamine to arginine amino acid substitution in the human Timeless gene (Q831R, A2634G), on diurnal preferences was studied in a random sample of normal volunteers enrolled in a population-based epidemiology study of the natural history of sleep dis...

Full description

Saved in:
Bibliographic Details
Published inSleep research online Vol. 3; no. 2; p. 73
Main Authors Pedrazzoli, M, Ling, L, Finn, L, Kubin, L, Young, T, Katzenberg, D, Mignot, E
Format Journal Article
LanguageEnglish
Published United States 2000
Subjects
Adult
Alleles
Cell Cycle Proteins
Circadian Rhythm - genetics
Circadian Rhythm - physiology
DNA - genetics
Female
Gene Frequency
Genotype
Humans
Intracellular Signaling Peptides and Proteins
Male
Middle Aged
Polymorphism, Single Nucleotide
Transcription Factors - genetics
Online AccessGet more information

Cover

More Information
Summary:The effect of a single nucleotide polymorphism, a glutamine to arginine amino acid substitution in the human Timeless gene (Q831R, A2634G), on diurnal preferences was studied in a random sample of normal volunteers enrolled in a population-based epidemiology study of the natural history of sleep disorders. We genotyped 528 subjects for this single nucleotide polymorphism and determined morningness-eveningness tendencies using the Horne-Ostberg questionnaire. Our results indicate that Q831R Timeless has no influence on morningness- eveningness tendencies in humans.
ISSN:1096-214X