Effects of open heart surgery under normothermic and hypothermic cardiopulmonary bypass on cytokines and complements

• Published in: Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA Vol. 23; no. 12; p. 1317
• Main Authors: Han, Pei-li, Fu, Qing-lin, Dong, Jian-feng, Zhang, Jie, Qin, Yuan-xu, Cui, Yu, Li, Qiang
• Format: Journal Article
• Language: Chinese
• Published: China 01.12.2003
• Subjects: Adolescent; Adult; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Child; Child, Preschool; Complement System Proteins - analysis; Female; Humans; Hypothermia, Induced; Interleukin-2 - blood; Male; Middle Aged; Tumor Necrosis Factor-alpha - analysis
• ISSN: 1000-2588

To explore the detrimental influence of normothermic and hypothermic cardiopulmonary bypass during open heart surgery on cytokines and complements. Forty patients with congenital or rheumatic heart disease were randomized into 2 groups to receive normothermic cardiopulmonary bypass (CPB, study group, n=20) or hypothermic CPB (control group, n=20). Venous blood samples were respectively collected at scheduled time points preoperatively, at the end of CPB, and 1,4,7,14 d postoperatively to examine the level of interleukin (IL)-2, tumor necrosis factor (TNF)-alpha, C3, and C4. IL-2 in both groups decreased significantly at the end of CPB, postoperative day 1 and 4, but recovered the normal level at day 7 postoperatively. IL-2 in control group was significantly lower than that in the study group at each time points at the end of CPB and day 1 and 4 postoperatively. TNF-alpha in two groups was both elevated at the time points cited above, and in the study group, recovery of normal TNF-alpha level occurred at day 7