A case of colon cancer with multiple liver metastases and lymph nodes metastases successfully treated by 5'-deoxy-5-fluorouridine

In a 79-year-old man with ascending colon cancer, multiple liver metastases were detected by computer tomography. The patient underwent right hemicolectomy. Paraaortic lymph nodes metastases were found intraoperatively. After surgery, 5'-deoxy-5-fluorouridine (5'-DFUR) was administered ora...

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Bibliographic Details
Published inGan to kagaku ryoho Vol. 29; no. 6; p. 955
Main Authors Hotokezaka, Masayuki, Ishimitsu, Toshiyuki, Matsumoto, Shinji, Nakamura, Kenjiro, Takeda, Shigeaki
Format Journal Article
LanguageJapanese
Published Japan 01.06.2002
Subjects
Administration, Oral
Aged
Antimetabolites, Antineoplastic - administration & dosage
Colonic Neoplasms - drug therapy
Colonic Neoplasms - pathology
Colonic Neoplasms - surgery
Drug Administration Schedule
Floxuridine - administration & dosage
Hepatectomy
Humans
Liver Neoplasms - secondary
Lymphatic Metastasis
Male
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Summary:In a 79-year-old man with ascending colon cancer, multiple liver metastases were detected by computer tomography. The patient underwent right hemicolectomy. Paraaortic lymph nodes metastases were found intraoperatively. After surgery, 5'-deoxy-5-fluorouridine (5'-DFUR) was administered orally at 600 mg daily. Abdominal CT showed disappearance of the liver metastases 6 months after operation. At a follow-up exam 24 months after the beginning of the chemotherapy, the patient remained in remission and reported no side effects. We consider oral administration of 5'-DFUR to be a useful treatment for advanced colon cancer.
ISSN:0385-0684