Effects of colforsin daropate hydrochloride in patients undergoing coronary artery bypass surgery

• Published in: Kyobu geka. The Japanese journal of thoracic surgery Vol. 54; no. 5; p. 391
• Main Authors: Hayashida, N, Chihara, S, Tayama, E, Kashikie, H, Takaseya, T, Hiratsuka, R, Kai, E, Enomoto, N, Kawara, T, Aoyagi, S
• Format: Journal Article
• Language: Japanese
• Published: Japan 01.05.2001
• Subjects: Aged; Colforsin - analogs & derivatives; Colforsin - therapeutic use; Coronary Artery Bypass; Coronary Disease - physiopathology; Coronary Disease - surgery; Female; Hemodynamics - physiology; Humans; Male; Middle Aged; Vasodilator Agents - therapeutic use
• ISSN: 0021-5252

The effects of Adehl, colforsin daropate hydrochloride, on hemodynamics were studied in patients undergoing cardiac surgery. Twenty-six patients who underwent coronary artery bypass grafting were divided into two groups according to the intraoperative administration of Adehl. The control group (n = 14) received no Adehl treatment and the Adehl group (n = 12) received Adehl infusion immediately after anesthesia induction (0.5 microgram.kg-1.min-1) for 6 hours. Hemodynamic measurements and clinical results were accessed perioperatively. The Adehl group resulted in significantly (p < 0.05) lower pulmonary capillary wedge pressure and systemic vascular resistance, and significantly (p < 0.05) greater cardiac indices and left ventricular stroke work indices than those in the control group. No significant difference was found in the rate pressure product between the groups. The Adehl group resulted in significantly shorter duration of intubation and ICU stay. Adehl was not associated with a significant increase in the prevalence of adverse effects. The results suggest that Adehl has positive inotropic and vasodilator effects without increasing myocardial oxygen consumption. Thus, it is suggested that Adehl can be a useful agent for the perioperative management in patients undergoing cardiac surgery.