Qualitative reasoning for AIDS treatment

We present a qualitative model of the interaction between HIV-1 virus and human cell, based on qualitative process theory. This model can be regarded as a first step for setting up a comprehensive model of the HIV 1 infection treatment in which the possible points where a drug can attack the virus a...

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Bibliographic Details
Published inJournal of clinical computing Vol. 22; no. 2-3; p. 2
Main Authors Giacomini, M, Ruggiero, C, Gaglio, S
Format Journal Article
LanguageEnglish
Published United States 01.04.1994
Subjects
Acquired Immunodeficiency Syndrome - drug therapy
Acquired Immunodeficiency Syndrome - prevention & control
Cell Division - physiology
Computer Simulation
Drug Design
Expert Systems
HIV-1 - drug effects
HIV-1 - growth & development
Humans
Italy
Models, Biological
RNA-Directed DNA Polymerase
Italy
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Summary:We present a qualitative model of the interaction between HIV-1 virus and human cell, based on qualitative process theory. This model can be regarded as a first step for setting up a comprehensive model of the HIV 1 infection treatment in which the possible points where a drug can attack the virus are evidentiated. The first simulation trials indicate that the model reproduces the major features of the real behavior of the virus inside and outside the human cell.
ISSN:0090-1091