Long-term study of tiopronin in patients with cystinuria

Thirty two patients with cystinuria were enrolled in this long-term study and 16 patients were treated with tiopronin for 24 weeks. Tiopronin reduced daily urinary cystine excretion from 901.48 mg (before treatment) to 488.60 mg (on the average of 12th week and 24th week after tiopronin administrati...

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Published inHinyokika kiyo. Acta urologica Japonica Vol. 49; no. 2; p. 115
Main Authors Koide, Takuo, Yoshioka, Toshiaki, Miyake, Osamu, Okuyama, Akihiko, Yachiku, Sunao
Format Journal Article
LanguageJapanese
Published Japan 01.02.2003
Subjects
Adult
Aged
Anorexia - chemically induced
Constipation - chemically induced
Cystinuria - drug therapy
Cystinuria - prevention & control
Dose-Response Relationship, Drug
Drug Administration Schedule
Female
Humans
Male
Middle Aged
Tiopronin - administration & dosage
Tiopronin - adverse effects
Tiopronin - therapeutic use
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Summary:Thirty two patients with cystinuria were enrolled in this long-term study and 16 patients were treated with tiopronin for 24 weeks. Tiopronin reduced daily urinary cystine excretion from 901.48 mg (before treatment) to 488.60 mg (on the average of 12th week and 24th week after tiopronin administration) successfully. Tiopronin therapy was tolerated well, but side effects were observed in 13 events in 6 patients. Thus tiopronin was expected to be effective in preventing cystine stone formation and tolerated well.
ISSN:0018-1994