High dose chemotherapy and allogenic peripheral blood stem cell transplantation for multiple myeloma evolving from intra-abdominal plasmacytoma

• Published in: Zhonghua yi xue za zhi (Taipei, Taiwan) Vol. 65; no. 11; p. 557
• Main Authors: Chung, Kun-Ming, Chuang, Shih-Sung, Hwang, Wei-Shou, Lee, Po-Shing, Li, Chin-Yang
• Format: Journal Article
• Language: English
• Published: China (Republic : 1949- ) 01.11.2002
• Subjects: Abdominal Neoplasms - complications; Adult; Combined Modality Therapy; Female; Hematopoietic Stem Cell Transplantation; Humans; Melphalan - administration & dosage; Multiple Myeloma - therapy; Plasmacytoma - complications; Prednisolone - administration & dosage; Transplantation, Homologous
• ISSN: 0578-1337

Solitary plasmacytomas include extramedullary plasmacytomas and those found in the bone. Seventy percent of patients are male and the median age is 50-55 years, younger than that for plasma cell myeloma. Most solitary plasmacytomas of bone eventually evolve to plasma cell myeloma within 2-10 years, while the extramedullary ones do so infrequently. We present an unusual case of intra-abdominal plasmacytoma in a young woman which was misdiagnosed and treated as T cell lymphoma initially. Typical manifestations of plasma cell myeloma appeared one year later. High dose chemotherapy followed by allogeneic peripheral stem cell blood transplantation (allo-PBSCT) was given. Relapse in skin occurred one year after allo-PBSCT, and was treated with wide excision and local irradiation. The patient was well and alive without evidence of disease 4 years after wide excision of the recurrence of chest wall solitary plasmacytoma and local radiotherapy.