Study on the active spirostanol saponins of Gualou xiebai baijiutang

To study the basis of actions of Gualou xiebai baijiutang. Guided by bioactivities, chemical and chromatographic ways were applied to isolate and purify the prescription. The chemical structures were identified by chemical and spectral ways. The activities on cardiovascular system of the pure compou...

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Bibliographic Details
Published inYao hsüeh hsüeh pao Vol. 38; no. 6; p. 433
Main Authors He, Xiang-jiu, Wang, Nai-li, Qiu, Feng, Yao, Xin-sheng
Format Journal Article
LanguageChinese
Published China 01.06.2003
Subjects
Allium - chemistry
Animals
Drug Combinations
Drugs, Chinese Herbal - chemistry
Drugs, Chinese Herbal - isolation & purification
Drugs, Chinese Herbal - pharmacology
Ethanol
Fruit - chemistry
Molecular Structure
Plants, Medicinal - chemistry
Platelet Aggregation - drug effects
Rabbits
Saponins - chemistry
Saponins - isolation & purification
Saponins - pharmacology
Trichosanthes - chemistry
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Summary:To study the basis of actions of Gualou xiebai baijiutang. Guided by bioactivities, chemical and chromatographic ways were applied to isolate and purify the prescription. The chemical structures were identified by chemical and spectral ways. The activities on cardiovascular system of the pure compounds were measured. Seven steroidal compounds were isolated and identified from the active parts. Compounds 5 and 6 showed good anti-platelet aggregation activities induced by ADP and PAF. The IC50 of compound 5 and 6 induced by 2 mumol.L-1 ADP were 0.082 and 0.078 mmol.L-1, and the IC50 induced by 0.5 mumol.L-1 PAF were 0.182 and 0.151 mmol.L-1, respectively.
ISSN:0513-4870