Resuscitation of newborn infants with oxygen

The metabolites of reoxygenation accumulate as toxic free radicals during physiological reactions. During an episode of asphyxia, 100% oxygen rather than 21% oxygen is usually used for resuscitation. Excessive free radicals and cell injury may be produced during reoxygenation following the hypoxic e...

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Bibliographic Details
Published inHu li za zhi Vol. 51; no. 1; p. 81
Main Authors Weng, Min-Hsueh, Chou, Cheng-Chen, Chou, Hung-Chieh, Lee, Tsorng-Yeh
Format Journal Article
LanguageChinese
Published China (Republic : 1949- ) 01.02.2004
Subjects
Asphyxia Neonatorum - therapy
Humans
Infant, Newborn
Oxygen Inhalation Therapy
Resuscitation - methods
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Summary:The metabolites of reoxygenation accumulate as toxic free radicals during physiological reactions. During an episode of asphyxia, 100% oxygen rather than 21% oxygen is usually used for resuscitation. Excessive free radicals and cell injury may be produced during reoxygenation following the hypoxic event. Prior research has shown that resuscitation with room air (21% oxygen) may be equally effective as 100% oxygen. The side effects are also less with room air. However, evidence-based studies on this topic are limited. It is, therefore, more appropriate to follow the recommendation of Neonatal Resuscitation Program that 100% oxygen should be used during neonatal resuscitation and the oxygen concentration should be adjusted according to the different condition of individual infants.
ISSN:0047-262X