A case of advanced gastric cancer with bulky N2 lymph node metastases resected after successful treatment with TS-1

We report a case of advanced gastric cancer with bulky N2 lymph node metastases resected after successful treatment with novel oral anticancer drug TS-1 as a neoadjuvant chemotherapy (NAC). A 62-year-old man was admitted to our hospital complaining of epigastralgia and dysphagia. Endoscopic examinat...

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Bibliographic Details
Published inGan to kagaku ryoho Vol. 31; no. 6; p. 935
Main Authors Takashima, Takeshi, Kashiwagi, Kiyoteru, Sasaki, Kenichi, Inoue, Daisei, Maeda, Hiroki, Shibuya, Hitoshi, Hirata, Koichi
Format Journal Article
LanguageJapanese
Published Japan 01.06.2004
Subjects
Adenocarcinoma - drug therapy
Adenocarcinoma - secondary
Adenocarcinoma - surgery
Antimetabolites, Antineoplastic - therapeutic use
Combined Modality Therapy
Drug Administration Schedule
Drug Combinations
Gastrectomy
Humans
Lymph Node Excision
Lymphatic Metastasis
Male
Middle Aged
Oxonic Acid - therapeutic use
Preoperative Care
Pyridines - therapeutic use
Remission Induction
Stomach Neoplasms - drug therapy
Stomach Neoplasms - pathology
Stomach Neoplasms - surgery
Tegafur - therapeutic use
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Summary:We report a case of advanced gastric cancer with bulky N2 lymph node metastases resected after successful treatment with novel oral anticancer drug TS-1 as a neoadjuvant chemotherapy (NAC). A 62-year-old man was admitted to our hospital complaining of epigastralgia and dysphagia. Endoscopic examination revealed type 3 advanced gastric cancer in the upper gastric body. Computed tomography (CT) showed bulky N2 lymph node metastases. He was treated with a daily dose of 120 mg of TS-1 for 4 consecutive weeks, followed by 2 weeks of rest. No serious adverse reaction was observed. After 1 course of treatment, the primary tumor and metastatic lymph nodes were reduced. Therefore, a total gastrectomy combined with splenectomy and D2 lymph node dissection was performed. Histopathologically, a few viable cancer cells remained in the resected stomach and metastatic lymph nodes were found. The histological effect of NAC was judged to be grade 2. The patient's postoperative course was uneventful, and he has been well for 11 months following surgery. TS-1 as NAC is considered to be effective for advanced gastric cancer.
ISSN:0385-0684