Hematopoietic progenitor colony formation in the immunopathogenesis of the autoimmune disorder in MRL/MpJ-lpr mice

Lymphocyte proliferation and apoptosis at different stages of the development of the autoimmune disorder in MRL/MpJ-lpr mice was studied. Hematopoietic progenitor colony formation during the course of the disease was characterized. A detectable difference at the level of lymphocyte proliferation, ap...

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Published inRussian journal of immunology : RJI : official journal of Russian Society of Immunology Vol. 7; no. 3; p. 245
Main Authors Toporkova, Ludmila B, Dubrovskaya, Viktoriya V, Sakhno, Ludmila V, Tikhonova, Marina A, Chernykh, Elena R, Buneva, Valentina N, Nevinsky, Georgy A, Kozlov, Vladimir A, Orlovskaya, Irina A
Format Journal Article
LanguageEnglish
Published Russia (Federation) 01.10.2002
Subjects
Animals
Apoptosis - immunology
Autoimmune Diseases - etiology
Autoimmune Diseases - immunology
Autoimmune Diseases - pathology
Cell Division - immunology
Cell Line
Hematopoietic Stem Cells - immunology
Hematopoietic Stem Cells - pathology
In Vitro Techniques
Lymph Nodes - immunology
Lymphocytes - immunology
Mice
Mice, Inbred MRL lpr
Proteinuria - genetics
Proteinuria - metabolism
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Summary:Lymphocyte proliferation and apoptosis at different stages of the development of the autoimmune disorder in MRL/MpJ-lpr mice was studied. Hematopoietic progenitor colony formation during the course of the disease was characterized. A detectable difference at the level of lymphocyte proliferation, apoptosis, and the relative amount of BFU-E, CFU-GM and CFU-GEMM cell colonies was revealed between healthy young mice and animals spontaneously developing pronounced symptoms of the autoimmune disorder. The quantity of BFU-E and CFU-GEMM colonies was remarkably increases in aged MRL/MpJ-lpr mice even before clinical manifestation of the disease (proteinuria). An elevated number of CFU-GEMM was accompanied by a striking increase in their size. The study of hematopoietic disturbances in autoimmune MRL/MpJ-lpr mice may be very useful for understanding the mechanism of the autoimmune disease development and searching for new strategies of the correction of the autoimmune disorder.
ISSN:1028-7221