Placental soluble fms-like tyrosine-kinase-1 (sFlt-1) in pregnant women with preeclampsia

The pathophysiology of preeclampsia remains largely unknown. A number of circulating placenta-produced factors have been implicated in causing the endothelial dysfunction and the clinical phenotype characteristic of preeclampsia. Determination of serum levels of placental soluble fms-like tyrosine-k...

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Published inFolia medica (Plovdiv) Vol. 46; no. 1; p. 19
Main Authors Dimitrakova, Elena D, Dimitrakov, Jordan D, Karumanchi, S A, Karumanchi, S G, Pehlivanov, Blagovest K, Milchev, Nikola P, Dimitrakov, Dimitar I
Format Journal Article
LanguageEnglish
Published Bulgaria 2004
Subjects
Adult
Enzyme-Linked Immunosorbent Assay
Extracellular Matrix Proteins - blood
Female
Humans
Placenta - metabolism
Pre-Eclampsia - blood
Pre-Eclampsia - physiopathology
Pregnancy
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Summary:The pathophysiology of preeclampsia remains largely unknown. A number of circulating placenta-produced factors have been implicated in causing the endothelial dysfunction and the clinical phenotype characteristic of preeclampsia. Determination of serum levels of placental soluble fms-like tyrosine-kinase-1 (sFlt-1) in pregnant women with preeclampsia. Eleven pregnant women with preeclampsia and 11 healthy women (controls) were included in the study. Determination of sFlt-1 was done with ELISA. The mean serum sFlt-1 levels of pregnant women with preeclampsia were twice as high as that of women with normal pregnancy. The highest level of sFlt-1 was found in women with severe preeclampsia. In women with mild form of preeclampsia the sFlt-1 level was close to that of the controls. sFlt-1 appears to be involved in the pathogenesis of preeclampsia and its serum levels can be used as a diagnostic marker of preeclampsia.
ISSN:0204-8043