Effect of the biodegradable chitosan external stent on the early changes in the rabbit vein grafts

• Published in: Chung-hua wai kʿo tsa chih Vol. 41; no. 9; p. 688
• Main Authors: Yang, Bin, Wu, Qing-yu, Li, Dian-yuan, Ruan, Ying-mao, Song, Min, Xie, Yong-quan
• Format: Journal Article
• Language: Chinese
• Published: China 01.09.2003
• Subjects: Animals; Biodegradation, Environmental; Chitin - administration & dosage; Chitin - analogs & derivatives; Chitosan; Female; Humans; Hyperplasia; Male; Proliferating Cell Nuclear Antigen - analysis; Rabbits; Stents; Tunica Intima - pathology; Veins - pathology; Veins - transplantation
• ISSN: 0529-5815

To investigate the effect of chitosan biodegradable external stent (CES) on the early changes of rabbit vein graft (VG). Rabbit vein grafting models were divided into S group (with perivenous CES) and NS group (without perivenous CES). The VG were harvested in 1 week, 2 weeks, 4 weeks after operation, respectively. The expression of proliferating cell nuclear antigen (PCNA) was used for evaluating the proliferation of the smooth muscle cell (SMC). The thickness, area of neointima and media of the VG were calculated by computer imaging analysis system. CES began to degrade in 2 weeks after operation. The thickness, area of both neointima and media of the VG in S group, increased mildly in 1 week after operation, and kept steady in 1 or 2 weeks after grafting, which was significantly less than NS group (both P < 0.01), then increased mildly in 4 weeks after grafting but still less than NS group (P < 0.05). The expression of PCNA of SMC decreased significantly in comparison with NS group though increasing mildly