Gastrin producing G-cells after chronic ethanol and low protein nutrition

• Published in: Indian journal of experimental biology Vol. 36; no. 11; p. 1093
• Main Authors: Koko, V, Todorović, V, Varagić, J, Micev, M, Korać, A, Bajcetić, M, Cakić-Milosević, M, Nedeljković, M, Drndarević, N
• Format: Journal Article
• Language: English
• Published: India 01.11.1998
• Subjects: Alcoholism - metabolism; Alcoholism - pathology; Animals; Dietary Proteins - administration & dosage; Gastrin-Secreting Cells - metabolism; Gastrin-Secreting Cells - ultrastructure; Gastrins - biosynthesis; Male; Microscopy, Electron; Nutrition Disorders - metabolism; Nutrition Disorders - pathology; Rats; Rats, Wistar
• ISSN: 0019-5189

Male Wistar rats, (2 months old), randomly divided according to the diet offered to four groups (C-control; A- alcoholized, PD-protein-deprived, A-PD- alcoholized protein-deprived). In group A and A-PD rats, the number of gastrin producing G-cells was significantly lower. The volume density of G-cells was significantly decreased in alcoholic rats. Fasting serum gastrin level (FSGL) significantly raised due to combined effect of alcohol consumption and protein malnutrition. In group A rats, the profile area of G-cells and their nuclei increased. In PD rats, the profile area of G cells also increased. There were no differences in nucleus/cell ratio due to alcohol ingestion alone, but it decreased significantly in PD and A-PD rats. Pale and lucent types of granules were predominantly seen in G-cells of animals of group A and A-PD. Mean diameter of granules increased in A, PD and A-PD rats. Other endocrine cells (ECL, D, EC) also decreased in number in A rats. Somatostatin producing D-cells decreased significantly in A-PD rats, both in fundic and pyloric mucosa.