Gastrin producing G-cells after chronic ethanol and low protein nutrition

Male Wistar rats, (2 months old), randomly divided according to the diet offered to four groups (C-control; A- alcoholized, PD-protein-deprived, A-PD- alcoholized protein-deprived). In group A and A-PD rats, the number of gastrin producing G-cells was significantly lower. The volume density of G-cel...

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Bibliographic Details
Published inIndian journal of experimental biology Vol. 36; no. 11; p. 1093
Main Authors Koko, V, Todorović, V, Varagić, J, Micev, M, Korać, A, Bajcetić, M, Cakić-Milosević, M, Nedeljković, M, Drndarević, N
Format Journal Article
LanguageEnglish
Published India 01.11.1998
Subjects
Alcoholism - metabolism
Alcoholism - pathology
Animals
Dietary Proteins - administration & dosage
Gastrin-Secreting Cells - metabolism
Gastrin-Secreting Cells - ultrastructure
Gastrins - biosynthesis
Male
Microscopy, Electron
Nutrition Disorders - metabolism
Nutrition Disorders - pathology
Rats
Rats, Wistar
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Summary:Male Wistar rats, (2 months old), randomly divided according to the diet offered to four groups (C-control; A- alcoholized, PD-protein-deprived, A-PD- alcoholized protein-deprived). In group A and A-PD rats, the number of gastrin producing G-cells was significantly lower. The volume density of G-cells was significantly decreased in alcoholic rats. Fasting serum gastrin level (FSGL) significantly raised due to combined effect of alcohol consumption and protein malnutrition. In group A rats, the profile area of G-cells and their nuclei increased. In PD rats, the profile area of G cells also increased. There were no differences in nucleus/cell ratio due to alcohol ingestion alone, but it decreased significantly in PD and A-PD rats. Pale and lucent types of granules were predominantly seen in G-cells of animals of group A and A-PD. Mean diameter of granules increased in A, PD and A-PD rats. Other endocrine cells (ECL, D, EC) also decreased in number in A rats. Somatostatin producing D-cells decreased significantly in A-PD rats, both in fundic and pyloric mucosa.
ISSN:0019-5189