The interaction of MS and pregnancy: a critical review

Previous research on the effects of pregnancy on multiple sclerosis (MS) is somewhat flawed, and well-controlled, well-designed studies are needed to validate trial findings. In general, pregnancy appears to have a protective effect on MS course, with fewer, less severe relapses, especially in the t...

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Bibliographic Details
Published inInternational MS journal Vol. 10; no. 2; p. 38
Main Authors Dwosh, E, Guimond, C, Duquette, P, Sadovnick, A D
Format Journal Article
LanguageEnglish
Published England 01.06.2003
Subjects
Estrogens - metabolism
Female
Humans
Multiple Sclerosis, Relapsing-Remitting - metabolism
Pregnancy
Pregnancy Complications
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Summary:Previous research on the effects of pregnancy on multiple sclerosis (MS) is somewhat flawed, and well-controlled, well-designed studies are needed to validate trial findings. In general, pregnancy appears to have a protective effect on MS course, with fewer, less severe relapses, especially in the third trimester. The exacerbation rate is increased in the first 3 months after delivery, but the overall relapse rate is no different to that observed in non-pregnant MS patients. A woman's past history of relapses may be the best indicator of clinical course during and immediately after pregnancy. Pregnancy does not appear to affect the long-term course of MS.
ISSN:1352-8963