Effect of jiangu granule on quality of bone in model rats with osteoporosis induced by ovariectomy

• Published in: Zhongguo Zhong xi yi jie he za zhi Vol. 24; no. 5; p. 431
• Main Authors: Lin, Yan-ping, Zhou, Rui-xiang, Guo, Shi-ming
• Format: Journal Article
• Language: Chinese
• Published: China 01.05.2004
• Subjects: Absorptiometry, Photon; Animals; Biomechanical Phenomena; Bone Density - drug effects; Drugs, Chinese Herbal - pharmacology; Drugs, Chinese Herbal - therapeutic use; Female; Osteoporosis - drug therapy; Osteoporosis - etiology; Osteoporosis - metabolism; Ovariectomy; Phytotherapy; Random Allocation; Rats; Rats, Sprague-Dawley
• ISSN: 1003-5370

To study the effect of Jiangu granule (JGG) on quality of bone in model rats with osteoporosis. Osteoporosis model was established by means of ovariectomy. Bone mineral density (BMD) was measured with dual energy X-ray densitometry. Osseous tissue structure of upper tibia was observed by ono-decalcified section and toluidine blue staining, and morphometry was carried out. Compressive strength limit and elastic modulus of first lumbar vertebrae, and bend load of femur were measured by light-based elastometer. JGG can significantly increase BMD, area of trabecula and thickness of bone cortex/diameter of marrow cavity ratio of model rats, to elevate the compressive strength limit of vertebrae and bend load of femur. JGG could increase BMD of osteoporosis model rats, and also could effectively improve the structure of osseous tissue, biomechanical property of bone and enhance the overall quality of bone.