Effect of jiangu granule on quality of bone in model rats with osteoporosis induced by ovariectomy

To study the effect of Jiangu granule (JGG) on quality of bone in model rats with osteoporosis. Osteoporosis model was established by means of ovariectomy. Bone mineral density (BMD) was measured with dual energy X-ray densitometry. Osseous tissue structure of upper tibia was observed by ono-decalci...

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Published inZhongguo Zhong xi yi jie he za zhi Vol. 24; no. 5; p. 431
Main Authors Lin, Yan-ping, Zhou, Rui-xiang, Guo, Shi-ming
Format Journal Article
LanguageChinese
Published China 01.05.2004
Subjects
Absorptiometry, Photon
Animals
Biomechanical Phenomena
Bone Density - drug effects
Drugs, Chinese Herbal - pharmacology
Drugs, Chinese Herbal - therapeutic use
Female
Osteoporosis - drug therapy
Osteoporosis - etiology
Osteoporosis - metabolism
Ovariectomy
Phytotherapy
Random Allocation
Rats
Rats, Sprague-Dawley
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Summary:To study the effect of Jiangu granule (JGG) on quality of bone in model rats with osteoporosis. Osteoporosis model was established by means of ovariectomy. Bone mineral density (BMD) was measured with dual energy X-ray densitometry. Osseous tissue structure of upper tibia was observed by ono-decalcified section and toluidine blue staining, and morphometry was carried out. Compressive strength limit and elastic modulus of first lumbar vertebrae, and bend load of femur were measured by light-based elastometer. JGG can significantly increase BMD, area of trabecula and thickness of bone cortex/diameter of marrow cavity ratio of model rats, to elevate the compressive strength limit of vertebrae and bend load of femur. JGG could increase BMD of osteoporosis model rats, and also could effectively improve the structure of osseous tissue, biomechanical property of bone and enhance the overall quality of bone.
ISSN:1003-5370