Effects of hypertonic saline, HAES and dimethylsulphoxide on free oxygen radicals in haemorrhagic shock oxygen radicals in haemorrhagic shock

• Published in: Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES Vol. 9; no. 3; pp. 154 - 159
• Main Authors: Bayir, Aysegül, Kafali, M Ertuğrul, Ak, Ahmet, Sahin, Mustafa, Karagözoğlu, Emrah, Gül, Mehmet, Karabulut, Kaan
• Format: Journal Article
• Language: English
• Published: Turkey 01.07.2003
• Subjects: Animals; Dimethyl Sulfoxide - administration & dosage; Dimethyl Sulfoxide - therapeutic use; Disease Models, Animal; Erythrocytes - metabolism; Free Radical Scavengers - administration & dosage; Free Radical Scavengers - therapeutic use; Infusions, Intravenous; Intestine, Small - metabolism; Lactic Acid - blood; Lactic Acid - metabolism; Liver - metabolism; Rabbits; Saline Solution, Hypertonic - administration & dosage; Saline Solution, Hypertonic - therapeutic use; Shock, Hemorrhagic - therapy; Thiobarbituric Acid Reactive Substances - metabolism
• ISSN: 1306-696X

The aim of this study was to investigate the effects of antioxidant and resuscitation fluids which were used during haemorrhagic shock on tissue ischemia. Forty New Zealand type rabbits were divided into four groups as C (control), I (hypertonic saline), H (HAES) and D (Dimethylsulphoxide-DMSO). Haemorrhagic shock was induced by bleeding from carotid artery. Thirty minutes after shock, Group C was not resuscitated while Group I was resuscitated with Hypertonic saline 7.2, Group H with 10 % HAES and Group D with HAES 10 % and DMSO. Thiobarbituric acid reactive substances (TBARS) and lactate levels in blood, liver and small bowel samples were measured. There were no significant differences among the groups tissue and plasma TBARS and lactate levels. Resuscitation fluids and addition of antioxidants to the resuscitation fluids do not have any superiorities over each other to prevent tissue ischemic insult in haemorrhagic shock.