A case of advanced gastric cancer resected after successful treatment with the novel oral anticancer drug TS-1

We report a case of advanced gastric cancer resected after successful treatment with the novel oral anticancer drug TS-1. The patient was a 52-year-old male. Gastrointestinal fiberscopy showed advanced gastric cancer. Examinations by computed tomography revealed gastric cancer invasion of the pancre...

Full description

Saved in:
Bibliographic Details
Published inGan to kagaku ryoho Vol. 30; no. 4; p. 531
Main Authors Koyama, Motoi, Inaba, Yukio, Watabe, Shuichi, Hayashi, Ken-ichi, Tsuge, Tohru, Kamio, Yukinori, Chiba, Masakazu, Tamura, Masaaki
Format Journal Article
LanguageJapanese
Published Japan 01.04.2003
Subjects
Adenocarcinoma - drug therapy
Adenocarcinoma - secondary
Adenocarcinoma - surgery
Administration, Oral
Antimetabolites, Antineoplastic - administration & dosage
Drug Administration Schedule
Drug Combinations
Gastrectomy
Humans
Lymph Nodes - pathology
Lymphatic Metastasis
Male
Middle Aged
Neoplasm Staging
Oxonic Acid - administration & dosage
Pyridines - administration & dosage
Stomach Neoplasms - drug therapy
Stomach Neoplasms - pathology
Stomach Neoplasms - surgery
Tegafur - administration & dosage
Online AccessGet more information

Cover

More Information
Summary:We report a case of advanced gastric cancer resected after successful treatment with the novel oral anticancer drug TS-1. The patient was a 52-year-old male. Gastrointestinal fiberscopy showed advanced gastric cancer. Examinations by computed tomography revealed gastric cancer invasion of the pancreas and swollen para-aortic lymph nodes. This patient was treated by preoperative chemotherapy with oral administration of TS-1 (120 mg per day). After 3 courses of treatment of TS-1, the primary lesion and swollen lymph nodes were remarkably reduced. This chemotherapy enabled total gastrectomy in curative resection. The pathological effectiveness of chemotherapy was Grade 1b in the primary lesion and Grade 2 or 3 in the lymph nodes. The patient sustained few side effects. This preoperative chemotherapy regimen seems to be an effective and promising therapy for patients with advanced gastric cancer.
ISSN:0385-0684