New nucleoside analogs in the treatment of hematological disorders
Cytotoxic nucleoside analogs have a broad clinical use. They were among the first chemotherapeutic agents used in the treatment of malignant diseases. The anticancer nucleosides include analogs of physiologic pyrimidine and purine nucleosides. They are used in oncology in the treatment of both, soli...
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Published in | Acta Poloniae pharmaceutica Vol. 61; no. 3; p. 223 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Poland
01.05.2004
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Abstract | Cytotoxic nucleoside analogs have a broad clinical use. They were among the first chemotherapeutic agents used in the treatment of malignant diseases. The anticancer nucleosides include analogs of physiologic pyrimidine and purine nucleosides. They are used in oncology in the treatment of both, solid tumors and hematological malignancies. These agents have many intracellular targets, e.g. they act as antimetabolites, competing with natural nucleosides during DNA or RNA synthesis and as inhibitors of key cell enzymes. Understanding of the mechanisms of action of these compounds and synthesis of new analogs provides the possibility to further expand the spectrum of their clinical use and enhance their antitumor activity. In this paper we describe mechanisms of action and possible clinical use in the treatment of hematological malignancies of these nucleoside analogs, which are now in different stages of clinical trials, namely tezacitabine, troxacitabine, clofarabine, nelarabine, decitabine, CNDAC and ECyD. |
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AbstractList | Cytotoxic nucleoside analogs have a broad clinical use. They were among the first chemotherapeutic agents used in the treatment of malignant diseases. The anticancer nucleosides include analogs of physiologic pyrimidine and purine nucleosides. They are used in oncology in the treatment of both, solid tumors and hematological malignancies. These agents have many intracellular targets, e.g. they act as antimetabolites, competing with natural nucleosides during DNA or RNA synthesis and as inhibitors of key cell enzymes. Understanding of the mechanisms of action of these compounds and synthesis of new analogs provides the possibility to further expand the spectrum of their clinical use and enhance their antitumor activity. In this paper we describe mechanisms of action and possible clinical use in the treatment of hematological malignancies of these nucleoside analogs, which are now in different stages of clinical trials, namely tezacitabine, troxacitabine, clofarabine, nelarabine, decitabine, CNDAC and ECyD. |
Author | Skierski, Janusz S Stachnik, Krzysztof J Szafraniec, Sylwia I |
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SubjectTerms | Adenine Nucleotides Animals Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Arabinonucleosides - adverse effects Arabinonucleosides - pharmacokinetics Arabinonucleosides - therapeutic use Clinical Trials as Topic Cytarabine - adverse effects Cytarabine - analogs & derivatives Cytarabine - therapeutic use Cytosine - adverse effects Cytosine - analogs & derivatives Cytosine - therapeutic use Deoxycytidine - adverse effects Deoxycytidine - analogs & derivatives Deoxycytidine - therapeutic use Dioxolanes - adverse effects Dioxolanes - therapeutic use Half-Life Hematologic Neoplasms - drug therapy Humans Purine Nucleosides - adverse effects Purine Nucleosides - therapeutic use Pyrimidine Nucleosides - adverse effects Pyrimidine Nucleosides - therapeutic use Stereoisomerism |
Title | New nucleoside analogs in the treatment of hematological disorders |
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