Study of interaction of gastrointestinal agents in the presence of cytoprotective drugs. Part II. In vitro study on the adsorption of selected spasmolytic drugs on sucralfate

The subject of the research was the adsorption of selected musculotropic and cholinolytic spasmolytics on a cytoprotective drug--sucralfate. Adsorption evaluation was made by a static method, in vitro, the environment reaction, the concentrations of the tested drugs and the sucralfate form being tak...

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Bibliographic Details
Published inActa Poloniae pharmaceutica Vol. 58; no. 6; p. 473
Main Authors Pluta, J, Grimling, B
Format Journal Article
LanguageEnglish
Published Poland 01.11.2001
Subjects
Adsorption - drug effects
Anti-Ulcer Agents - chemistry
Anti-Ulcer Agents - pharmacokinetics
Cytoprotection
Drug Interactions
Gastrointestinal Agents - chemistry
Gastrointestinal Agents - pharmacokinetics
Parasympatholytics - chemistry
Parasympatholytics - pharmacokinetics
Sucralfate - chemistry
Sucralfate - pharmacokinetics
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ISSN0001-6837

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Summary:The subject of the research was the adsorption of selected musculotropic and cholinolytic spasmolytics on a cytoprotective drug--sucralfate. Adsorption evaluation was made by a static method, in vitro, the environment reaction, the concentrations of the tested drugs and the sucralfate form being taken into account. The obtained results prove that the analysed therapeutic substances are adsorbed on the sucralfate in all pH. The highest bonding capacity was observed in tests at pH=3.6, in the presence of sucralfate, which at this pH occurs in the form of suspension. The lowest capacity was at pH=1.5 in the presence of sucralfate in the paste form. In the group of the tested drugs, scopolamine butylbromide is adsorbed best, drotaverine hydrochloride little less and papaverine hydrochloride least of all.
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ISSN:0001-6837