Analysis of 602 cases of nevus of Ota and study of ultrastructures on the melanocytes

• Published in: Zhōngguó yīxué kēxuéyuàn xuébào Vol. 25; no. 5; p. 590
• Main Authors: Wang, Hong-wei, Wang, Jia-bi, Liu, Yue-hua, Fang, Kai, Jiang, Guo-tiao, Zuo, Ya-gang
• Format: Journal Article
• Language: Chinese
• Published: China 01.10.2003
• Subjects: Adolescent; Adult; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Laser Therapy; Male; Melanocytes - ultrastructure; Melanosomes - radiation effects; Melanosomes - ultrastructure; Nevus of Ota - radiotherapy; Nevus of Ota - ultrastructure; Skin - ultrastructure; Skin Neoplasms - radiotherapy; Skin Neoplasms - ultrastructure
• ISSN: 1000-503X

To analyze clinical information and efficacy of 602 cases of nevus of Ota, and investigate the histopathology and ultrastructure on the melanocytes before and after Q-switched Alexandrite laser irradiation. Clinical information of 602 cases of nevus of Ota were collected by applying clinical records, checking photos, and inquiry to patients by letters and telephones. Ten cases of biopsies were observed by light microscopy and 6 cases by electron microscopy before and after laser irradiation. Nevus of Ota included congenital and acquired cases. Skin lesions mainly occurred in adolescence for the acquired cases. The main colours of lesions were brown and blue. The most local lesions were zygomata, temporal regions, and lower eyelids. According to multiple regression, the more treatment times, the better results. The effective rate was 85.20% and 100% after 6 and 9 treatment times, respectively, while the cure rate was 55.72% and 98.46%, respectively. The eyelids involved and Tanino types influenced the treatmen