Synthesis and structure-activity relationships of novel nikkomycin analogs: inhibitors of the fungal cell wall biosynthesis enzyme chitin synthase

A series of novel nikkomycin analogs, which inhibited chitin synthase, the fungal cell wall biosynthesis enzyme, has been synthesized and evaluated their inhibitory activities.

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Bibliographic Details
Published inNucleic acids symposium series (1979) no. 42; pp. 13 - 14
Main Authors Uda, J, Obi, K, Iwase, K, Sugimoto, O, Ebisu, H, Matsuda, A
Format Journal Article
LanguageEnglish
Published England 1999
Subjects
Aminoglycosides
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antifungal Agents - chemical synthesis
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
Chitin Synthase - antagonists & inhibitors
Drug Design
Enzyme Inhibitors - chemical synthesis
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - pharmacology
Models, Molecular
Structure-Activity Relationship
Uridine Diphosphate N-Acetylglucosamine - chemistry
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Summary:A series of novel nikkomycin analogs, which inhibited chitin synthase, the fungal cell wall biosynthesis enzyme, has been synthesized and evaluated their inhibitory activities.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0261-3166