The plasma levels of urokinase plasminogen activator and urokinase plasminogen activator receptor and plasminogen activator inhibitor-1 in patients with different stages of liver cirrhosis following chronic hepatitis B

• Published in: Zhonghua gan zang bing za zhi Vol. 12; no. 2; p. 82
• Main Authors: Wu, Xi-run, Wang, Qi, Shi, Shui-sheng, Lu, Ming-he, Guo, Wen-dong
• Format: Journal Article
• Language: Chinese
• Published: China 01.02.2004
• Subjects: Female; Hepatitis B, Chronic - complications; Humans; Liver Cirrhosis - blood; Male; Middle Aged; Plasminogen Activator Inhibitor 1 - blood; Receptors, Cell Surface - blood; Receptors, Urokinase Plasminogen Activator; Urokinase-Type Plasminogen Activator - blood
• ISSN: 1007-3418

To measure the plasma levels of urokinase plasminogen activator (uPA), urokinase plasminogen activator receptor (uPAR) and plasminogen activator inhibitor-1 (PAI-1), and study the relationship between the plasma levels of uPA, PAI-1 and the serum albumin (Alb), collagen type IV (CIV), the serum hyaluronic acid (HA), prothrombin time (PT) and prothrombin activity (PTA) in patients with different stages of liver cirrhosis following chronic hepatitis B. 72 cases with liver cirrhosis of different stages were classified according to child-pugh's categories A, B, C, in which there were 23 cases in child A, 29 cases in child B, and 20 cases in child C. The plasma levels of uPA, uPAR, PAI-1 and the serum levels of HA, CIV were detected by ELISA. The serum PCIII concentration was determined by radioimmunoassay. With the progression of hepatic fibrosis, the plasma levels of uPA, uPAR and PAI-1 were (1.36+/-0.43) microg/L, (3.03+/-1.48) microg/L and (24.09+/-7.14) microg/L respectively in group A, (1.79+/-0.62) microg/L