A case of typical Melkersson-Rosenthal syndrome with possible autosomal dominant inheritance

Here we presented a case of 40-year-old woman who suffered from bilateral facial palsy and headache. She had allegedly had an episode of facial palsy, and facial edema at her age of 14 years. Physical examination revealed swelling of the lips, upward disturbance of the left eye, hypogeusia, the fiss...

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Bibliographic Details
Published inRinshō shinkeigaku Vol. 39; no. 10; p. 1020
Main Authors Goto, A, Kume, A, Aiba, I, Yasuda, T, Murakami, N
Format Journal Article
LanguageJapanese
Published Japan 01.10.1999
Subjects
Administration, Oral
Adult
Ageusia - drug therapy
Anti-Inflammatory Agents - administration & dosage
Facial Paralysis - drug therapy
Female
Genes, Dominant
Humans
Melkersson-Rosenthal Syndrome - drug therapy
Melkersson-Rosenthal Syndrome - genetics
Pedigree
Prednisolone - administration & dosage
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Summary:Here we presented a case of 40-year-old woman who suffered from bilateral facial palsy and headache. She had allegedly had an episode of facial palsy, and facial edema at her age of 14 years. Physical examination revealed swelling of the lips, upward disturbance of the left eye, hypogeusia, the fissured tongue, and bilateral facial palsy. Oral administration of prednisolone 20 mg/day yielded gradual but complete improvement of the facial palsy and hypogeusia within two weeks. Careful analysis of family history disclosed that four members had oro-facio-cervical edema and three had the fissured tongue. A diagnosis of Melkersson-Rosenthal syndrome with possible autosomal dominant inheritance was made based on the clinical findings and familial aggregation of the incomplete form of this syndrome.
ISSN:0009-918X