A case of fluvoxamine overdose

Selective serotonin reuptake inhibitors (SSRI) are newly developed-antidepressants authorized in 1999 in Japan. We experienced a case of drug poisoning including fluvoxamine, one of SSRI. A comatose nineteen-year-old girl was transported to our ER in the morning on July 25, 2000. There remained many...

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Bibliographic Details
Published inChudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology Vol. 15; no. 1; p. 53
Main Authors Oka, Hiroyasu, Shirakawa, Yoichi, Koyama, Kazuhiro, Maekawa, Soichi, Hirota, Masami, Nishizaki, Osamu, Fukumoto, Shinya, Ochi, Genro
Format Journal Article
LanguageJapanese
Published Japan 01.01.2002
Subjects
Adult
Antidepressive Agents - blood
Antidepressive Agents - poisoning
Chromatography, High Pressure Liquid
Drug Overdose
Female
Fluvoxamine - blood
Fluvoxamine - poisoning
Humans
Serotonin Uptake Inhibitors - blood
Serotonin Uptake Inhibitors - poisoning
Time Factors
Tranquilizing Agents - blood
Tranquilizing Agents - poisoning
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Summary:Selective serotonin reuptake inhibitors (SSRI) are newly developed-antidepressants authorized in 1999 in Japan. We experienced a case of drug poisoning including fluvoxamine, one of SSRI. A comatose nineteen-year-old girl was transported to our ER in the morning on July 25, 2000. There remained many empty packages of fluvoxamine and several sorts of tranquilizers in the room. Her consciousness became alert over the next morning. HPLC analysis revealed fluvoxamine, chlorpromazine, promethazine, biperiden, phenobarbital, and zopiclone in her blood and that serum concentrations of the first three were above the therapeutic ranges. The peak values of fluvoxamine, chlorpromazine, and promethazine were 1,343 ng/ml (6.7 times of the upper limit), 861 ng/ml (2 times), and 529 ng/ml (1.3 times), respectively. Fluvoxamine must be a main cause of her toxic symptoms although other CNS-depressing drugs might work jointly.
ISSN:0914-3777