Relationship of I/D polymorphism of angiotensin converting enzyme gene with hypertension in Xinjiang Kazakh isolated group

• Published in: Zhonghua yi xue yi chuan xue za zhi Vol. 20; no. 3; p. 253
• Main Authors: Wang, Xiao-feng, Wang, Shi-zhen, Lin, Ren-yong, Cheng, Zu-heng, Ding, Jian-bin, Jia, Mi-la, Wen, Hao, Wu, Gui-zhen, Lu, Xiao-mei
• Format: Journal Article
• Language: Chinese
• Published: China 01.06.2003
• Subjects: Asian Continental Ancestry Group - genetics; Blood Pressure - genetics; China - ethnology; Female; Gene Frequency; Humans; Hypertension - genetics; INDEL Mutation; Male; Middle Aged; Peptidyl-Dipeptidase A - genetics; Polymorphism, Genetic; Population Groups; China
• ISSN: 1003-9406

To investigate whether the insertion/deletion(I/D) polymorphism in the angiotensin converting enzyme(ACE) gene is associated with essential hypertension in Xinjiang Kazakh isolated population. The study covered 201 hypertensives and 151 normotensive controls in Xinjiang Barlikun Kazakh population. The I/D polymorphism of ACE gene was determined by polymerase chain reaction. The frequencies of D and I in the hypertensive group (0.44 and 0.56, respectively) were not significantly different from the controls(0.39 and 0.61, respectively, P=0.16). The frequencies of ACE genotypes of DD, ID, and II were 0.18, 0.52, 0.30 in hypertensives respectively and 0.17, 0.43, 0.40 in control group respectively. There was no significant difference in genotypes between hypertensive group and normotensive group (P=0.14). The results suggested that the I/D polymorphism of ACE gene might not be associated with hypertension in the Kazakh population of Xinjiang Barlikun area.