Non-small cell lung cancer with liver metastasis responsive to gemcitabine--a case report

A 56-year-old male patient underwent a right upper lobectomy and lymph node dissection for non-small cell lung cancer in March 1994. Multiple lung metastases in the right lung were found 45 months after the operation, and chemotherapy with docetaxel was administered. A liver metastasis was detected...

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Published inGan to kagaku ryoho Vol. 28; no. 5; p. 707
Main Authors Sakurai, T, Oura, S, Yoshimasu, T, Tanino, H, Kokawa, Y, Nakamura, T, Matsuyama, K, Naito, Y
Format Journal Article
LanguageJapanese
Published Japan 01.05.2001
Subjects
Adenocarcinoma - drug therapy
Adenocarcinoma - secondary
Antimetabolites, Antineoplastic - administration & dosage
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Deoxycytidine - administration & dosage
Deoxycytidine - analogs & derivatives
Drug Administration Schedule
Humans
Liver Neoplasms - drug therapy
Liver Neoplasms - secondary
Lung Neoplasms - drug therapy
Lung Neoplasms - pathology
Male
Middle Aged
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Summary:A 56-year-old male patient underwent a right upper lobectomy and lymph node dissection for non-small cell lung cancer in March 1994. Multiple lung metastases in the right lung were found 45 months after the operation, and chemotherapy with docetaxel was administered. A liver metastasis was detected 11 months later, and it was refractory to docetaxel. Therefore, the patient was treated with cisplatin, mitomycin C and vinorelbine, which resulted in no change to the liver metastasis. He was next treated with gemcitabine, which resulted in a partial response of the liver metastasis. The adverse effects of gemcitabine were Grade 3 thrombocytopenia and Grade 2 neutropenia. The response duration for gemcitabine therapy was three months.
ISSN:0385-0684